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pentobarbital will minimize the extent or impact of acalabrutinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital will lower the extent or outcome of lumefantrine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with solid CYP3A4 inducers may end up in reduced se